John Spencer Selected Research

ferrocene

2/2019	Cytotoxic Activity of the Histone Deacetylase 3-Selective Inhibitor Pojamide on MDA-MB-231 Triple-Negative Breast Cancer Cells.
8/2018	Probing the Anticancer Action of Novel Ferrocene Analogues of MNK Inhibitors.
11/2012	Cytotoxic effects of Jay Amin hydroxamic acid (JAHA), a ferrocene-based class I histone deacetylase inhibitor, on triple-negative MDA-MB231 breast cancer cells.
2/2009	Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones.

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John Spencer Research Topics

Disease

14	Neoplasms (Cancer) 03/2021 - 12/2009
9	Breast Neoplasms (Breast Cancer) 03/2021 - 11/2012
3	Infections 03/2021 - 05/2014
3	Iron Overload 01/2019 - 03/2012
2	COVID-19 01/2022 - 03/2021
2	Disease Progression 01/2021 - 03/2016
2	Triple Negative Breast Neoplasms 02/2019 - 08/2018
2	Inflammation (Inflammations) 12/2017 - 01/2013
2	Epilepsy (Aura) 01/2015 - 09/2010
1	Adenocarcinoma 03/2021
1	Lysosomal Storage Diseases (Lysosomal Storage Disease) 01/2021
1	Ataxia (Dyssynergia) 01/2021
1	Sandhoff Disease (Sandhoff's Disease) 01/2021
1	GM2 Gangliosidoses (GM2 Gangliosidosis) 01/2021
1	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 01/2021
1	Hemosiderosis 01/2019
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 08/2018
1	Pain (Aches) 12/2017
1	Neoplasm Metastasis (Metastasis) 01/2017
1	Dystonia (Limb Dystonia) 01/2016
1	Parkinsonian Disorders (Parkinsonism) 01/2016
1	Alzheimer Disease (Alzheimer's Disease) 01/2015
1	Drug Resistant Epilepsy 01/2015
1	Neurodegenerative Diseases (Neurodegenerative Disease) 07/2014
1	Carcinoma (Carcinomatosis) 09/2013
1	Dental Caries (Decay, Dental) 06/2009
1	Experimental Melanoma 02/2009

Drug/Important Bio-Agent (IBA)

6	Proteins (Proteins, Gene)FDA Link 10/2019 - 03/2006
4	ferroceneIBA 02/2019 - 02/2009
4	Histone Deacetylase InhibitorsIBA 12/2017 - 11/2012
3	Pharmaceutical PreparationsIBA 07/2016 - 01/2015
2	Molecular Chaperones (Chaperone, Molecular)IBA 03/2021 - 10/2019
2	carbazoleIBA 03/2021 - 01/2016
2	Histones (Histone)IBA 03/2021 - 02/2019
2	Eukaryotic Initiation Factor-4EIBA 03/2018 - 01/2017
2	Biological ProductsIBA 12/2017 - 07/2016
2	Fatty Acids (Saturated Fatty Acids)IBA 12/2017 - 01/2015
2	Phosphotransferases (Kinase)IBA 07/2016 - 02/2009
2	DeferiproneIBA 08/2015 - 03/2012
2	Chelating AgentsIBA 07/2014 - 03/2012
1	teriflunomideIBA 01/2022
1	Leflunomide (Arava)FDA LinkGeneric 01/2022
1	Antirheumatic Agents (DMARD)IBA 01/2022
1	CarbazolesIBA 03/2021
1	acetylleucineIBA 01/2021
1	Leucine (L-Leucine)FDA Link 01/2021
1	Neuroprotective AgentsIBA 01/2021
1	DNA (Deoxyribonucleic Acid)IBA 01/2020
1	Codon (Codons)IBA 01/2020
1	Histone Deacetylases (Histone Deacetylase)IBA 02/2019
1	Deferasirox FDA Link 01/2019
1	Benzoic Acid (Potassium Benzoate)FDA Link 01/2019
1	ProteomeIBA 12/2017
1	EndocannabinoidsIBA 12/2017
1	Anti-Anxiety Agents (Anxiolytics)IBA 12/2017
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 12/2017
1	Cannabinoid Receptors (Cannabinoid Receptor)IBA 12/2017
1	Ornithine Carbamoyltransferase (Ornithine Transcarbamylase)IBA 01/2017
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 11/2016
1	Antineoplastic Agents (Antineoplastics)IBA 07/2016
1	Vorinostat FDA Link 07/2016
1	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA 07/2016
1	AsparagineIBA 03/2016
1	2- amino- 1- methyl- 6- phenylimidazo(4,5- b)pyridineIBA 03/2016
1	LigandsIBA 01/2016
1	ManganeseIBA 01/2016
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 10/2015
1	EstersIBA 05/2015
1	benzeneboronic acidIBA 05/2015
1	Plasminogen InactivatorsIBA 05/2015
1	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 05/2015
1	AcidsIBA 05/2015
1	Coloring Agents (Dyes)IBA 03/2015
1	octanoic acid (caprylic acid)IBA 01/2015
1	Pentylenetetrazole (Metrazol)IBA 01/2015
1	Triglycerides (Triacylglycerol)IBA 01/2015
1	Valproic Acid (Depakote)FDA LinkGeneric 01/2015
1	CarbonIBA 05/2014
1	1-methyl-4-phenyl-3 -(1H-pyrrol-1-yl)-1H-pyrazoleIBA 07/2013
1	Arachidonic Acid (Vitamin F)IBA 01/2013
1	jay amin hydroxamic acidIBA 11/2012
1	MetalsIBA 11/2012
1	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2012
1	IronIBA 03/2012
1	Hypnotics and Sedatives (Sedatives)IBA 09/2010
1	Cathepsin BIBA 12/2009
1	Cytotoxins (Cytolysins)IBA 12/2009
1	EnzymesIBA 12/2009
1	FluoridesIBA 06/2009
1	SolutionsIBA 02/2009

Therapy/Procedure

7	Therapeutics 11/2020 - 03/2006
1	Critical Care (Surgical Intensive Care) 03/2021
1	Extracorporeal Membrane Oxygenation 03/2021
1	Treatment Delay 01/2021
1	Off-Label Use 01/2021
1	Blood Transfusion (Blood Transfusions) 01/2019
1	Ketogenic Diet 01/2015
1	Drug Therapy (Chemotherapy) 05/2014
1	Nephroureterectomy 09/2013
1	Fluoridation 06/2009